MAP kinase phosphorylates a repressor of translation initiation [4E-binding protein (BP) 1] that binds to the mRNA 5' cap binding protein eukaryotic initiation ...

The translation re-pressor protein S8, encoded by rpsH, binds to the rplE translation initiation region and represses L5 synthesis by competing with 30S ...

May 9, 2017 · Here, we identified the mRNA cap-binding eIF4E-related protein 4EHP as an effector of miRNA-mediated translation repression. Through screening ...

Jan 17, 2018 · These RBPs can control recruitment of the mRNAs to the ribosome and regulate the rate of protein synthesis or alternatively, repress mRNA ...

Dendritic BC1 RNA regulates translation initiation by interacting with eIF4A and PABP, repressing formation of the 48S translation initiation complex. BC1 RNA ...

Jun 21, 2017 · These mRNAs' 3'UTRs have enriched binding motifs for several RNA-binding proteins, which implies extensive translational regulatory networks.

Nov 15, 1995 · Here, we have studied the mechanism by which 4E‐BP1 inhibits translation. We show that 4E‐BP1 inhibits 48S pre‐initiation complex formation.

Oct 1, 2004 · The cytoplasmic-polyadenylation-element-binding protein (CPEB) regulates the translation of maternal mRNA during vertebrate oocyte maturation ...

Aug 24, 2023 · The regulation of translation provides a rapid and direct mechanism to modulate the cellular proteome. In eukaryotes, an established model ...

eIF4E, the cap-binding protein promotes protein synthesis by binding to eIF4G. Beside its role in translation regulation, eIF4E is also important for mRNA ...